• Thalassemia and Transfusion: a Tango for Two (THALATTA 4/2), 2019-2024 supported by the Special Account for Research Grants (SARG) # 20241

Omics signatures of disease in transfusion-dependent thalassemia (TDT) patients

RBC physiology and RBC-based diagnostic markers in hematological malignancies

Size distribution and immunophenotyping of plasma extracellular vesicles in diseases.

RBC membrane disorders in Greek population: diagnosis, features and association with thalassemia traits

Molecular enhancement of RBC storage solutions

• Congenital dyserythropoietic anemias, 1996-2001
• RBC membrane disorders, 1996-1999 (General Secretariat for Research and Innovation, GSRI, YPER program)
• RBC proteins in inherited and acquired diseases, 1999-2001 (PENED program)
• RBC storage lesion in CPDA preservative solution, 2005
• RBC membrane proteins in diabetic retinopathy, 2005-2008

• RBC-derived extracellular vesicles during storage, 2006-2008
• RBC aging during storage in CPD-SAGM preservative solution , 2008-2010
• Characterization of microvesicles in units of Fresh Frozen Plasma, 2011-2015 (Hellenic Society of Blood Transfusion)
• Follow-up study of RBC biology in End Stage Renal Disease, 2009-2014
• Apolipoprotein J/Clusterin in RBCs, 2009-2011
• Effect of pre-storage leukoreduction on RBC storage lesion with emphasis to the accumulation of extracellular vesicles, 2010-2020

 Donor variation effects on RBC storage lesion, 2013-
a) Serum uric acid levels, 2013-2017
b) G6PD deficiency, 2014-2022
c) Red cell osmotic fragility, 2016-2022
d) Sex, 2018-2020
e) beta-thalassemia traits, 2015-2022

f) Storability and Post-transfusion Performance of Erythrocytes from beta-Thalassemia minor Donors, 2018-2022, Supported by the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Innovation (GSRI), Grant agreement No. 2032

g) Supplementation of RBC storage solutions with antioxidants, 2020-2022, Operational Program “Human Resources Development, Education and Lifelong Learning”, Reinforcement of Postdoctoral Researchers – 2nd Cycle” (MIS-5033021), State Scholarships Foundation (ΙΚΥ)

• Recipient variation effects on the performance of transfused RBCs:
a) Uremic plasma, 2016-2018
b) Plasma from G6PD-deficient subjects
c) Plasma from beta-thalassemia major patients

 RBC proteasomes: regulation, topology, activity, 2020-
• RBC characteristics in ESRD patients resistant to erythropoietin therapy, 2015-2017
• Hemodiafiltration versus conventional hemodialysis on RBC performance, 2015-2017
• Study of Fresh Frozen Plasma from G6PD-deficient donors, 2015-2017
• Coagulation abnormalities in renal pathology, 2018-2020
• Post-storage performance of RBCs from beta-thalassemia trait donors (mouse model), 2019-2020
• Free vs. vesicular Hb in units of stored RBCs, 2012-2021

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