B. Red cell storage lesion - Donor and Recipient variation effects on transfusion efficacy and outcomes

Relevant publications

1. Membrane protein carbonylation in non-leukodepleted CPDA-preserved red blood cells. Blood Cells Mol Dis, 2006.


2. Progressive oxidation of cytoskeletal proteins and accumulation of denatured hemoglobin in stored red cells. J Cell Mol Med, 2007. https://doi.org/10.1111/j.1582-4934.2007.00008.x
3. Storage-dependent remodeling of the red blood cell membrane is associated with increased immunoglobulin G binding, lipid raft rearrangement and caspase activation. Transfusion, 2007. https://doi.org/10.1111/j.1537-2995.2007.01254.x
4. Red blood cell aging markers during storage in citrate-phosphate-dextrose–saline-adenine-glucose-mannitol. Transfusion, 2010. https://doi.org/10.1111/j.1537-2995.2009.02449.x
5. Aging and death signaling in mature red cells: from basic science to transfusion practice. Antonelou MH, Kriebardis AG, Papassideri IS. Blood Transfus, 2010. https://doi.org/10.2450/2010.007S
6. Effects of pre-storage leukoreduction on stored red blood cells signaling: a time-course evaluation from shape to proteome. J Proteomics, 2012. https://doi.org/10.1016/j.jprot. 2012.06.032
7. Uric acid variation among regular blood donors is indicative of red blood cells susceptibility to storage lesion markers: a new hypothesis tested. Transfusion, 2015. https://doi.org/10.1111/trf.13211
8. An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion, 2015. https://doi.org/10.1111/trf.12804
9. Donor variation effect on red blood cell storage lesion: a multi-parameter, yet consistent, story. Transfusion, 2016 https://doi.org/10.1111/trf.13582
10. Glucose 6-phosphate dehydrogenase deficient subjects may be better “storers” than donors of red blood cells. Free Radic Biol Med, 2016. https://doi.org/10.1016/j.freeradbiomed. 2016.04.005
11. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Data Brief, 2016. https://doi.org/10.1016/j.dib.2016.06.018
12. Donor-variation effect on red blood cell storage lesion: A close relationship emerges. Proteom Clin Appl, 2016. https://doi.org/10.1002/prca.201500128
13. Insights into red blood cell storage lesion: toward a new appreciation. Antonelou MH, Seghatchian J. Transfus Apher Sci,2016. https://doi.org/10.1016/j.transci.2016.10.019
14. Temperature-dependent haemolytic propensity of CPDA-1 stored erythrocytes vs. whole blood - Red cell fragility as a donor’s signature on blood units. Blood Transfus, 2017. https://doi.org/10.2450/2017.0332-16
15. Unraveling the Gordian knot: red blood cell storage lesion and transfusion outcomes. Blood Transfus, 2017. https://doi.org/10.2450/2017.0313-16
16. Red blood cell transfusion in surgical cancer patients: Targets, risks, mechanistic understanding and further therapeutic opportunities. Transfus Apher Sci, 2017. https://doi.org/10.1016/j.transci.2017.05.015
17. Erythrocyte-based drug delivery in Transfusion Medicine: Wandering questions seeking answers. Transfus Apher Sci; 2017. https://doi.org/10.1016/j.transci.2017.07.015
18. Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage. Haematologica, 2018. https://doi.org/10.3324/haematol.2017.178608
19. Donor-specific individuality of red blood cell performance during storage is partly a function of serum uric acid levels. Transfusion, 2018. https://doi.org/10.1111/trf.14379
20. Metabolic linkage and correlations to storage capacity in erythrocytes from glucose 6-phosphate dehydrogenase deficient donors. Front Med, 2018. https://doi.org/10.3389/fmed.2017.00248
21. Redox status, procoagulant activity and metabolome of fresh frozen plasma in glucose 6-phosphate dehydrogenase deficiency. Front Med, 2018. https://doi.org/10.3389/fmed.2018.00016
22. Red cell transfusion in paediatric Red cell transfusion in paediatric patients with thalassaemia and sickle cell disease: Current status, challenges and perspectives. Transfus Apher Sci, 2018. https://doi.org/10.1016/j.transci.2018.05.018
23. Recipient’s effects on stored red blood cell performance: the case of uremic plasma. Transfusion, 2019. https://doi.org/10.1111/trf.15257
24. Ex vivo generation of transfusable red blood cells from various stem cell sources: A concise revisit of where we are now. Transfus Apher Sci, 2019. https://doi.org/10.1016/j.transci.2018.12.015
25. “Valar morghulis”: all red cells must die. Blood Transfus, 2020. https://doi.org/10.2450/2020.0028-20
26. When I need you most: frozen red blood cells for transfusion. Transfus Apher Sci, 2020. https://doi.org/10.1016/j.transci.2020.102786
27. Sex-related aspects of the red blood cell storage lesion. Blood Transfus, 2021. https://doi.org/10.2450/2020.0141-20
28. Red cell proteasome modulation by storage, redox metabolism and transfusion. Blood Transfus, 2022. https://doi.org/10.2450/2020.0179-20
29. Beta-thalassemia minor is a beneficial determinant of red blood cell storage lesion. Haematologica, 2022. https://doi.org/10.3324/haematol.2020.273946
30. Proteome of stored RBC membrane and vesicles from heterozygous beta thalassemia donors. Int J Mol Sci, 2021. https://doi.org/10.3390/ijms22073369
31. Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. Transfusion, 2021. https://doi.org/10.1111/trf.16402
32. Osmotic hemolysis is a donor-specific feature of red blood cells under various storage conditions and genetic backgrounds. Transfusion, 2021. https://doi.org/10.1111/trf.16558
33. Red blood cell proteasome in beta-thalassemia trait: topology of activity and networking in blood bank conditions. Membranes, 2021. https://doi.org/10.3390/membranes11090716
34. The post-storage performance of RBCs from beta-thalassemia trait donors is related to their storability profile. Int J Mol Sci, 2021. https://doi.org/10.3390/ijms222212281
35. Corpuscular fragility and metabolic aspects of freshly drawn beta-thalassemia minor RBCs impact their physiology and performance post-transfusion: a triangular correlation analysis in vitro and in vivo. Biomedicines, 2022. https://doi.org/10.3390/biomedicines10030530
36. Early and late-phase 24h responses of stored red blood cells to recipient-mimicking conditions. Front Physiol, 2022.
37. Innate variability in physiological and omics aspects of the beta thalassemia trait-specific donor variation effects. Front Physiol, 2022. https://doi.org/10.3389/fphys.2022.907444
38. Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring. Redox Biol, 2022. https://doi.org/10.1016/j.redox.2022.102477
39. Tools and metrics for the assessment of post-storage performance of red blood cells: no one is left over. Transfusion, 2023.

40. The time-course linkage between hemolysis, redox, and metabolic parameters during red blood cell storage with or without uric acid and ascorbic acid supplementation. Frontiers in Aging, 2023.